• Author
    Nhuan Vu
  • Discovery PI

    Edmund Tsui, MD

  • Project Co-Author

    Justin Yun

  • Abstract Title

    Retinal Oxygen Saturation in Uveitic Disease

  • Discovery AOC Petal or Dual Degree Program

    Basic, Clinical, & Translational Research

  • Abstract

    Purpose: To evaluate retinal oxygen saturation (StO₂) using noninvasive retinal oximetry (Zilia) in the retina and optic nerve head and to assess its correlation with different uveitic pathologies.

    Methods: The Zilia Ocular device employs diffuse reflectance spectroscopy to continuously measure retinal oxygen saturation (StO₂), reflecting tissue oxygenation within the retinal vasculature. StO₂ may serve as a metabolic biomarker of disease severity. In this prospective observational study, adult participants are enrolled at the Uveitis Clinic at the Stein Eye Institute, University of California, Los Angeles. Retinal oximetry is performed using the Zilia Ocular fundus imaging system, a non-FDA-approved device that captures images to estimate oxygen saturation in both the optic nerve head and retina. Imaging is conducted during routine clinical visits. Differences in oxygen saturation across disease states will be compared and correlated with clinical examination findings and imaging characteristics.

    Results: Data collection and analysis are ongoing. Initial efforts have focused on establishing normative oxygen saturation ranges and identifying patterns associated with specific uveitic disease states.

    Conclusion: This study aims to characterize retinal oxygenation in healthy and diseased eyes and evaluate its utility as a biomarker for ocular pathology. Findings may provide insight into disease-related physiologic changes and inform future diagnostic and monitoring strategies.

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