• Author
    Khadija Agsalud
  • Discovery PI

    Irena Tsui

  • Project Co-Author

    YELI WANG, JENNY WU, MARCUS YAMAMOTO, CHRISTIAN ALTENBACH, ILINA PLUYM

  • Abstract Title

    Increased Choroidal Thickness in Hypertensive Disorders of Pregnancy in the Third Trimester

  • Discovery AOC Petal or Dual Degree Program

    Basic, Clinical, & Translational Research

  • Abstract

    Purpose: This study aims to describe clinical characteristics of the choroid in pregnant women with complications during the third trimester of pregnancy. 

    Methods: Pregnant women in the third trimester  (>28 weeks gestational age) of pregnancy underwent optical coherence tomography (OCT) imaging. Univariate comparisons between maternal pregnancy complications and choroidal outcomes were performed. Multivariable linear regression models were then constructed, adjusting for imaging time, preeclampsia, gestational diabetes, gestational hypertension, and intrauterine growth restriction (IUGR)/ small for gestational age (SGA). Main outcomes measured were subfoveal choroidal thickness (SFCT). 

    Results: Included were 39 patients (39 eyes) in total. In univariate analyses, subfoveal and average choroidal thickness were significantly thicker in pregnancies with gestational hypertension (P <0.05). In multivariable models, these associations persisted for both nasal (p = 0.023) and temporal thickness (p = 0.014).

    Conclusion:  Choroidal measurements by OCT demonstrated significant increased subfoveal thickness in mothers with gestational hypertension. This persisted when adjusted for other maternal comorbidities, such as OSA and diabetes. These findings are consistent with prior studies in patients with preeclampsia

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