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  • Author
    Nabill Munshi
  • PI

    Dr Robert Goldberg

  • Co-Author

    Dr Dan Rootman

  • Title

    Incidence and predictors of SLK in Thyroid Eye Disease

  • Program


  • Other Program (if not listed above)

  • Abstract


    Thyroid Eye Disease is an autoimmune disease that affects 20-25% of patients with Grave’s disease. Antibodies which target the Thyroid Stimulating Hormone Receptor (TSHR) have the ability to bind and activate the TSHR-Insulin like Growth Factor 1 receptors (IGF1-r) located on orbital fibroblasts and adipocytes which in turn produces an inflammatory environment. In the course of TED, the eyelids, orbital fat, orbital adnexa, ocular surface and extra ocular muscles have the potential to be affected. Signs and symptoms can vary from patient to patient making no one universal test able to determine disease severity. TED can be detrimental to patients both physiologically and psychologically, thus severely affecting a patients quality of life. In this study our focus will be on understanding SLK incidence in patients diagnosed with TED and what factors may contribute to SLK manifestation.


    A complete thyroid related history was taken following the VISA template. The presence of SLK was determined by the staining of lissamine green of the superior limbus. Other Thyroid Eye Disease markers such as changes to eyelid position, proptosis and strabismus were recorded. Ocular surface factors were also recorded. All data was extracted from Care Connect UCLA Electronic Health Record and stored in a TED related database for which incidence of SLK was calculated and binary and multivariate statistics were done on potential associated factors.


    Sample consisted of 268 patients of which the SLK incidence in this cohort was found to be 5%. Bivariate statistical analysis showed no known relationship/difference between various demographics, thyroid bloodwork, eyelid position and signs of corneal disease.


    Typical demographic, clinical and serum values of TED were not predictive of SLK. A clear relationship between SLK incidence and severity of TED or characteristics of TED were not found.


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