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  • Author
    Dana Song
  • Co-author

    Dana Song, Sammy Saab

  • Title

    Longā€term outcomes with oral therapy in liver transplant recipients with hepatitis B

  • Abstract

    Objective: The present study evaluates how oral antiviral agents impact long-term renal function in liver transplant recipients with a history of Hepatitis B. 
    Methods: We studied 79 patients who received a liver transplant for hepatitis B and were placed on all-oral antiviral therapy after withdrawing from hepatitis B immunoglobulin therapy at a single-institution tertiary care center. A retrospective chart review was conducted to obtain laboratory data. Univariate and two-sided t tests were performed. 
    Results: 22.8% (18/79) of recipients on any all-oral therapy regimen had worsening of their chronic kidney disease stage, and 17.7% (14/79) had an increase in creatinine of at least 0.3 mg/dL. There were no significant changes in creatinine and GFR in patients while on tenofovir alafenamide. 
    Conclusion: Oral antiviral agents generally worsen renal function in liver transplant recipients with a history of hepatitis B. However, tenofovir alafenamide appears to have less of an impact on renal function compared to other oral antiviral agents. 
     

  • College

    ACC

  • Zoom

    https://ucla.zoom.us/j/7047403919

  • PDF

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